The Randles lab is dedicated to applying innovative computational methods to the study of biological phenomena. We are passionate about transforming the future of health using massively parallel, personalized, computational simulations of the circulatory system. In particular, we are developing new technologies to enhance the spatial and temporal domains that can be captured in high fidelity fluid-structure-interaction simulations through efficient use of some of the world's biggest supercomputers. These image-based simulations can yield insight into the underlying mechanisms driving disease progression and inform surgical planning or the design of next generation drug delivery systems. Working closely with physicians and experimentalists, we are establishing a tightly coupled feedback loop between the mathematical model development and in vivo and in vitro measurements. Our research aims to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.
*Image created by Madhurima Vardhan, Duke Univeristy, and Liam Krauss, Lawrence Livermore National Laboratory.