The paper "Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations" from our collaboration with Lawrence Livermore National Laboratory will be presented at SPIE Photonics West in January.
Title: Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations
Author(s): Ted A. Laurence, Sonny S. Ly, Maxim Shusteff, Lawrence Livermore National Lab. (United States); Amanda Randles, John Gounley, Duke Univ. (United States); Erik Draeger, Lawrence Livermore National Lab. (United States)
The utility and accuracy of computational modeling often requires direct validation against experimental measurements. The work presented here is motivated by taking a combined experimental and computational approach to determine the ability of large-scale computational fluid dynamics (CFD) simulations to understand and predict the dynamics of circulating tumor cells in clinically relevant environments. We use stroboscopic light sheet fluorescence imaging to track the paths and measure the velocities of fluorescent microspheres throughout a human aorta model. Performed over complex physiologically –realistic 3D geometries, large data sets are acquired with microscopic resolution over macroscopic distances.