April 14, 2025 | New study reveals how specific features in arterial velocity waveforms affect hemodynamic simulations across coronary, pulmonary, and carotid arteries.
This work extends our "points of interest" approach beyond coronary arteries to identify key features in carotid and pulmonary waveforms that influence simulated blood flow. The study highlights the importance of waveform shape in clinical measurements and computational modeling.
We are excited to announce the publication of our latest work on the impact of temporal inlet waveform shape on vascular hemodynamics. Building on our lab’s prior methodology for coronary artery waveforms, this study extends our “points of interest” framework to pulmonary and carotid artery geometries to quantify how temporal features of blood flow waveforms influence simulated hemodynamic outcomes.
Justen Geddes led this team effort, using both 1D and 3D computational fluid dynamics simulations to systematically perturb specific points on measured waveforms and assess their impact on key metrics such as wall shear stress, oscillatory shear index, and relative residence time. The study reveals that not all points on a waveform contribute equally to flow dynamics—particularly emphasizing the influence of the secondary peak in pulmonary and carotid waveforms. These insights inform both simulation accuracy and the design of diagnostic measurement tools by identifying which features of a velocity waveform matter most for capturing physiologically relevant flow.
This work provides a robust and generalizable approach for quantifying sensitivity to inlet waveform shape and supports more precise modeling across vascular territories.
Read more: https://comphealth.duke.edu/publications/impact-of-inlet-velocity-waveform-shape-on-hemodynamics/
Geddes, J.R., King, T.D., Tanade, C., Ladd, W., Khan, N.S., & Randles, A. Impact of inlet velocity waveform shape on hemodynamics. Journal of Computational Science, 2025. https://doi.org/10.1016/j.jocs.2025.102579