July 10, 2025
We are thrilled to announce that Adaptive Physics Refinement for Anatomic Adhesive Dynamics Simulations paper by Aristotle Martin, William Ladd, Wendy Wu, and Amanda Randles has received the Best Main Track Paper Award at this week’s International Conference on Computational Science (ICCS 2025) in Singapore. The work demonstrates a groundbreaking hybrid CPU–GPU method that makes high-resolution, multiscale simulations of circulating tumor-cell adhesion both accurate and computationally feasible.
At the heart of this achievement is our Adaptive Physics Refinement (APR) framework, which couples a finely resolved adhesive-dynamics “window” to a larger fluid domain. Key innovations include:
- Movable Refinement Window: Dynamically traverses complex vessel geometries to capture ligand–receptor interactions in real time.
- GPU-Accelerated Adhesive Kernels: Dramatically reduces run time through on-the-fly data movement and optimized memory usage.
- Scalable Performance: Enables simulations of large microfluidic devices at a fraction of the cost and time of fully explicit models.
Congrats to the whole team and particularly Aristotle for leading this effort and for this outstanding recognition.