March 17, 2026 | Published in Cardiovascular Engineering and Technology
We are excited to share a new publication from the Randles Lab: “Real-Time Peripheral Revascularization Planning in Chronic Limb Threatening Ischemia Using HarVI: A Digital Twin Approach,” published in Cardiovascular Engineering and Technology (CVET).
This work, led by Cyrus Tanade, Christopher W. Jensen, Guinevere Ferreira, and Amanda Randles, introduces the first application of the HARVEY Virtual Intervention (HarVI) framework to peripheral artery disease (PAD), with a focus on patients with chronic limb-threatening ischemia (CLTI).
Although endovascular interventions such as angioplasty and stenting are routinely performed, clinicians currently lack tools that provide real-time, patient-specific predictions of hemodynamic outcomes to guide these procedures. HarVI addresses this gap by combining one-dimensional computational fluid dynamics (1D CFD) with machine learning to rapidly evaluate how different intervention strategies—such as changes in stenosis length or diameter—impact postoperative blood flow.
Using a retrospective cohort of patients with superficial femoral artery disease, the study demonstrates that HarVI accurately predicts postoperative peak systolic velocities, a clinically relevant metric measured by duplex ultrasound. The framework closely matches high-fidelity CFD simulations while enabling rapid exploration of a large space of potential intervention scenarios.
A key strength of this approach is its clinical translatability. The workflow integrates with standard imaging and physiological measurements already collected in routine care and can be initialized in under 10 minutes. Once trained, the model can return predictions in milliseconds, allowing clinicians to iteratively evaluate treatment options during a procedure.
Together, these results establish HarVI as a promising digital twin platform for real-time, patient-specific intervention planning in PAD, opening the door to more interactive, personalized, and data-driven vascular care.
Citation
Tanade, C., Jensen, C.W., Ferreira, G. et al. Real-Time Peripheral Revascularization Planning in Chronic Limb Threatening Ischemia Using HarVI: A Digital Twin Approach. Cardiovasc Eng Tech (2026). https://doi.org/10.1007/s13239-026-00825-1